Memory Functions of the Aging Brain are Provided By Imaging Study

There may be a link between the long-term episodic memory function of the brain and dopamine D2 receptors, according to researchers in Europe who have been using PET and MRI brain imaging to investigate.

As a result of dementia and age, episodic memory functions often become degraded. The research could then help explain why some people suffer from memory impairment. Results of the study were published in the July 12, 2016 issue of the journal Proceedings of the National Academy of Sciences (PNAS).

The study was conducted at Umea University in Umea, Sweden by researchers who used Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) brain imaging for the study. Statistical analyses were then used as well as post processing – including 3D imaging, to study the mechanisms behind memory degradation that occurs during aging.

Patient's brain with dementia

181 people aged 64 and 68 were recruited for the study. The participants took part in memory and processing speed tests, coupled with measurements of the different parts of the brain using an MRI assessment. Then, a PET camera was used to examine differences in the D2 system of the brains of the individuals.

It was found that the D2 system was positively linked to episodic memory. The system was not linked to processing speed or working memory. D2 systems were also investigated by the researchers to learn how the D2 was affecting hippocampus function.

The director at the Umea Centre for Functional Brain Imaging, professor Lars Nyberg, said, “Our results link the dopamine D2 receptor to long term episodic memory, likely via hippocampus functioning. Episodic memory is often reduced with age and in people with dementia. Hence, impairment of the dopamine system are important to consider when attempting to understand the bases of impaired cognitive abilities due to aging.”



Resource: Umea University


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