Wednesday, August 31, 2016

5 Awesome September Lake County Events

Who's as excited for Fall as I am? It's been one of the hottest summers on record here in Florida (and I'm pretty sure around the world as well,) so I'm more than ready to break out my sweaters, inhale pumpkin flavored everything, and lounge around a fire or two. It's not officially Fall till the end of September, but I like to pretend it starts the 1st. And on that note, Lake County has some cool things happening all of September to break in the Fall season. Check out our picks below!





Thursday, September 8th, 2016

Southern Hill Farms

16651 Schofield Road, Clermont

If you enjoy blueberries and pancakes, come out to Bouncing Blueberries for family fun activities, blueberry pancakes, story time for the kids, and blueberry muffins, local raw honey, blueberry jam, and more for sale,  Hayrides will also be available throughout the morning. 





Saturday, September 10th, 2016

Cadwell Park

4 Cassady St., Umatilla

At the Florida Wildlife Festival, the focus is on increased awareness and promotion of the safe co-existence of humans and wildlife. It’ll be a fun and educational even and will focus not only on the Florida black bear, but other native Florida species as well.





Saturday, September 10th, 2016

Clermont's Waterfront Park

330 3rd Street, Clermont

The Cool Summer Mornings 5K Series continues with Race #4, this time with a pirate theme. If you are an avid runner or even if you're just a beginner, come enjoy a morning filled with running, along with post-race food, beer, and live entertainment. 





Friday, September 16th – Sunday, September 18th, 2016

Renniger’s Antique Center

20651 U.S. 441, Mount Dora
Renniger’s is the source for antiques, and they’ll open again for the Vintage RV, Glamping, Hot Rod & Antiques Show. There will be plenty of antique, vintage, RV and car-related vendors, in addition to camp fires, movies, food, and more. There will also be a contest for Best Vintage RV, Best Vendor Display, and Best Campsite.





Saturday, September 17th, 2016

Mount Dora Community Building Theater

520 N. Baker Street, Mount Dora

Known as Broadway's best party, the Rock of Ages Band had a successful run for 6 years, ending in January of 2015. They are now bringing their party to Mount Dora, where they'll play hits from the glam and hair metal bands from the 80's, including Whitesnake, Quiet Riot, Ratt, Night Ranger, Foreigner, Journey, REO Speedwagon, Pat Benetar, and more!



Wednesday, August 24, 2016

Natural Pain Relief for Cancer Patients

For those that are diagnosed with cancer, chronic pain can become an almost constant battle. Tumors often put pressure on bones, organs, and even nerves; the chemicals that are secreted by tumors also can create pain. But the cancer itself isn’t the only source of cancer-related pain. When you are going through cancer treatments such as chemotherapy and radiation, living your daily life can be excruciating, and the doctor's answer is often to prescribe pain medication that is damaging and often addicting. This is the case with opioid painkillers such as codeine and morphine. When the pain becomes unbearable and the solutions offered by doctors create devastating side effects, it is time to look into natural pain relief in the form of herbs and supplements. Most of the herbs I will list below have anti-inflammatory properties that work by blocking the enzymes that trigger swelling and subsequent pain. Even though these herbs have been used as natural remedies for years in different cultures, please note that I am not a medical doctor and you should always consult with your physician before taking any natural herbs and/or supplements. 


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Tumeric:

Tumeric comes from India and is the spice that gives curry and yellow mustard its beautiful yellow color. Tumeric has long been praised for its anti-inflammatory properties, and the extract found in the turmeric root, curcumin, also possesses these properties. They also both have potent antioxidant properties. Curcumin especially is credited for its ability to reduce pain and slow deterioration in the body. Tumeric works by shutting down the COX2 enzyme that causes pain, as it's able to search for and destroy free radicals in your body. Some doctors even believe that tumeric is more precise than aspirin when it comes to shutting down inflammation. There are a couple different ways to get adequate amounts of turmeric in your diet in order for it to battle pain. Eating a lot of curried dishes, drinking turmeric tea, and taking a supplement (try to find one with the highest percent of curcumin extract) are all good ways to reach ideal levels. Tumeric is a safe alternative with no (known) side effects, so be sure to enjoy it regularly. (I especially love it on scrambled eggs, but if you're looking for more ideas, check out this awesome recipe post.)




Papain:

Papain is an enzyme that's found in papaya fruit and is derived from the sappy, milk like latex that comes from unripe papaya skins. The latex is dried and then made into a powder. Papain boosts the immune system by breaking down proteins, it attacks tumor cells, and was shown to protect against the damaging effects of radiation in animal studies. Papain is often applied topically for bed sores, burns, and surgical wounds; but is usually taken as a pain management supplement. Common side effects of papain include gastrointestinal distress when taken orally and mild burning when applied topically. The enzyme is easily found in supplement stores. 




Ginger:

Did you know ginger reduces pain and inflammation? Ginger lowers your number of prostaglandins, which are the messenger molecules that tell you when you're in pain. Since chemotherapy causes nausea in many cancer patients, ginger can help with that as well (since we all know the effect of ginger ale when we're sick.) The side effects of ginger are rare unless taken in incredibly high doses, but they include heartburn, diarrhea, and stomach discomfort. The herb can be bought fresh or dried, and you can also get it in capsule form, tinctures, extracts, and oils. It's also possible to grate the fresh root for recipes, as its extremely versatile (as you can tell from this awesome Buzzfeed article.) Ginger goes well with Indian/Asian dishes, soups, fish, desserts (like these simple ginger cookies,) and of course tea -- not to mention it pairs extremely well with tumeric and ginseng, two other herbs on this list. 



Capsaicin:

Capsaicin is the phenolic substance that is found in hot chili peppers, and there are plenty of studies that prove how well capsaicin is at pain management. Most of the time, it is used in topical pain relieving creams and patches, but it has also been shown to activate cell receptors in the intestinal lining, creating a reaction that lowers the risk of tumors. Researchers also believe that the compound may turn off an over-reactive receptor that could trigger tumor growth. Capsaicin has also been shown to be effective against breast, pancreatic, and bladder cancer cells. Side effects of capsaicin when eaten are stomach irritation, sweating, flushing, and runny nose. Taken in large doses capsaicin could possibly be dangerous and in rare cases could cause liver or kidney damage. (But that's rare, since I highly doubt many people are funneling tons of hot chili peppers down their throats.) And hey, if you can take the heat, here's a great list of 9 hot peppers and recipes to go with them. 




Feverfew:

Also known as wild chamomile, feverfew hails from the Balkan Mountains of eastern Europe, though nowadays it can be found throughout Europe, South America, and North America. It's been used as a treatment for migraines, fevers, stomach aches, toothaches, and other sources of pain for hundreds of years. There's a main ingredient in feverfew known as Parthenolide, and its responsible for much of its healing power, as it stops the spread of cancerous cells including those of breast, prostate, lung, bladder, leukemia, and myeloma. (Fun fact: the ancient Greeks called feverfew Parthenium, because it supposedly saved the life of someone who fell off the Parthenon during its construction.) It is most common to take feverfew as a supplement, and you can also make it into a tea (here's a good recipe.) You can also grow it in your garden if you are green-thumb inclined. (Me, not so much -- I kill plants just by looking at them.) With feverfew you are gaining not only the migraine and fever reducing advantages but the anti-cancer and anti-inflammatory properties as well. However, do proceed with caution when it comes to this herb as those allergic to the Asteraceae/Compositae plant family (this includes ragwee, chysanthemums, marigolds, daisies, and many others,) may have an allergic reaction with feverfew. Notable side effects of the herb include upset stomach, heartburn, diarrhea, constipation, bloating, and nausea; and pregnant women are advised not to take feverfew as there is concern for early contractions and/or miscarriage. 




Ginseng:

Ginseng is a very well known herb, mostly used as a natural energy booster and a fatigue combatant in cancer patients. New research linked to the compound "ginesenosides" found in ginseng reveal that the herb can kill cancer cells and inhibit cancer's uncontrolled growth, invasiveness, and angiogenesis. Cancer cells can break away from their primary site and spread to other parts of the body, and ginesenosides can inhibit cancer metastasis and decrease its invasive abilities. Non-toxic and safe, except for minor side effects such as diarrhea, itching, trouble sleeping, headaches, and nervousness, ginseng is recommended in the morning or early afternoon due to its stimulatory properties. Ginseng is most easily taken as a dried extract (200 milligrams,) a tea, or by taking 10 to 3 drops of the extract in a beverage. You can, however, use ginger in recipes, as shown on this ginseng Yummly page. (As mentioned above, ginseng is often used along with tumeric and ginger in recipes, so you get a triple whammy of healing properties!) 


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Overall, there are plenty of alternatives to the traditional cancer related pain solutions offered by pharmaceutical companies. A lot of the herbs listed above work just as well, if not better than, prescribed medication, but are just not as widely known about. Not to mention it's definitely useful that a lot of the herbs are extremely versatile and go well together in recipes. Even if you've never tried natural remedies before, it may be beneficial and money-saving to do so! Also, curry is one of the most delicious things on this planet. Just a side note. 



LOOK AT IT.


DISCLAIMER: All of the information above was gathered through research and reviews from various sources, but I am not a medical professional. If you are interested in taking any of the herbs above, please consult with your doctor before doing so, and know that there are always risks associated with any natural remedy, even if none were found and/or were listed. 


ClermontRadiology.com

Tuesday, August 16, 2016

The Genius of Marie Curie

If you know anything about radiology or how radiation helps treat cancer, you’ll know that none of today's advances in cancer treatments involving radiology would be possible without the discoveries of Marie Curie.

Born Maria Sklodowska in Warsaw, Poland on November 7th, 1867, she was raised in a time when Poland was under complete control by the czar of Russia, and her family struggled financially because of her father’s Polish patriotism.

By the time Marie graduated high school at the age of 15, her mother and sister had both died from tuberculosis and typhus, and she fell into a deep depression. She visited her cousins in the country to attempt to clear her head, and after returning to Warsaw, Marie and her sister Bronya joined a “floating university.” A floating university was necessary because at that time women were not allowed to study at the University of Warsaw. So, therefore, the classes met at night and in constantly changing locations to avoid detection by the czar’s police.

Marie with her sister Bronya - 1886.

Marie and her sister Bronya were very close and made a pact to help each other with their educations. Marie would work to help pay for Bronya’s schooling, and when Bronya was complete and making money, she would work to help pay for Marie’s schooling. Therefore Marie worked for three years as a governess teaching the children of a beet-sugar factory owner, and during this time a chemist in the factory gave her some lessons on chemistry. (Poles were forbidden to teach laboratory science.) She continued working as a governess after returning to Warsaw in 1889, while secretly studying chemistry at an illegal lab for Polish scientists.

Marie was finally able to head to medical school at Sorbonne University in Paris at the age of 24, and even though she struggled with tuition, rent, and food, she successfully completed her master’s degree in physics and math in three years, earning a scholarship in the process.

Around this time, Marie was paid by the Society for the Encouragement of National Industry to investigate the magnetic properties of different steels, but Marie didn’t have a lab. That was when she was introduced to Pierre Curie, who was the Laboratory Chief at the Paris Municipal School of Industrial Physics and Chemistry. By then, the Spring of 1894, he had already made important scientific discoveries on magnetism and crystals. Pierre convinced Marie to stay in Paris to pursue science, and she convinced him to write up his magnetism research and get a doctoral degree. Needless to say, they fell in love and married in July 1895.

Marie and Pierre Curie's wedding day - 1895.

For two years she completed her research on the magnetic properties of steels, before she had her first daughter, Irene, in 1897. By then, Marie was looking for a research topic that would earn her a doctorate in science, a degree that no woman in the world had completed yet; she then decided to investigate uranium rays.

She soon discovered that the strength of the rays that came out depended only on the amount of uranium in the compound. Usually, normal properties changed according to how you treated a substance, and scientists at that time knew that such properties came from the way atoms combined with one another. They believed that atoms themselves could not change since they had been created at the beginning of time. She decided to try out various chemicals, in which she found that compounds that contained thorium also gave out rays. To describe the behavior of these two elements, Marie made up the term “radioactivity.”

Marie continued to work her way through other compounds, and her husband Pierre worked with her. They eventually discovered two new elements present in the mineral pitchblende (which was rich in uranium) and they named one “polonium” after Poland, and the other “radium,” for the Latin word for ray.
Radium was discovered to be constantly putting out energy, and Pierre also proved that it could damage living flesh, which opened new ways for treating cancer and other diseases. Radium was soon extracted for medical uses and experiments by scientists.

Soon, Marie became the first woman faculty member at France’s top training school for women’s teachers, and in 1903 she completed her doctoral thesis. The committee of examiners even declared that her work had done more for science than any other previous thesis project.

Marie in 1903.

Her work was recognized in 1903 when she and her husband Pierre won the Nobel Prize in Physics in 1903. Pierre was then appointed to a professorship at Sorbonne University, and Marie was hired as a laboratory chief.

In 1906 disaster struck when Pierre slipped on wet pavement on the way to the library and fell in front of a horse-drawn carriage, which ran over his head and killed him instantly. Marie was, understandably, devastated, but she went back to work a day after the funeral. And less than a month later, Sorbonne made her the first woman professor, taking up Pierre’s position.

Around this time she created the Radium Institute with the help of the French government and scientist friends, where she headed the radioactivity lab. She also taught physical science once a week at a cooperative school, where her daughter Irene and a few other students got lessons from their parents.

Marie won a second Nobel Prize for her discovery of radium and polonium in 1911, and in 1914, as Germany invaded France, nearly every member of the staff at the Radium Institute enlisted in the war effort. Marie convinced wealthy people to donate their cars, and with them, she assembled a fleet of 20 mobile X-Ray stations as well as 200 stationary stations for doctors on the battlefield. Her teenage daughter Irene also helped as an assistant to her mother, and later directed X-Ray stations by herself. Marie also discovered that radioactive gas that comes from minerals containing radium could be prepared in tiny glass tubes and inserted into patients at spots where the radiation would destroy diseased tissue.

Marie driving a mobile X-Ray clinic - 1915.

The war ended in 1918, and Marie went back to raising money for the Radium Institute. She even came to America and gained a gram of radium so powerful it could fuel thousands of experiments, as well as expensive equipment and quite a bit of money for the institute.

The Radium Institute became a world center for research and Marie carefully selected several dozen scientists to work with. In 1934, her daughter Irene and son in law Frederic Joilot Curie discovered artificial radioactivity, but, sadly, Marie died before she could see them receive the 1935 Nobel Prize for their discovery. She died on July 4th, 1934 from aplastic anemia, which is a blood disease directly related to radiation exposure. Today, 83 years after her death, Marie Curie's possessions are still so radioactive that they cannot be handled without protection, most notably her notebooks. Her body was even placed in a coffin lined with an inch of lead. 

In 1995 Marie's remains, as well as Pierre’s, were transferred to the Pantheon in Paris, where they now lie among France’s greatest citizens. The president of France remarked that the transfer demonstrated the nation’s respect for all those, like the Curie’s, “who dedicate themselves to science.”

Marie with her daughter Irene - 1925

Without Marie Curie, we would not have the advanced treatments for cancer involving radiation that we have today. Other uses for radiation besides X-Ray technology include nuclear reactors, sterilization for medical equipment, and restoring eyesight to the blind.





Friday, August 12, 2016

Secrets from the World's Healthiest Countries

Living a long, healthy life with low risk of disease is what we all wish for. There's a new health fad released every week, clogging our newsfeeds and confusing our brains. A lot of the time, health fads turn out to be complete nonsense and leave us wondering where to turn. What's not a fad, however, are the international diets and societal norms that have been consumed and practiced for hundreds, if not thousands of years. And, as it's already been proven, these cultural habits are the key to a long, healthy life. 

You might have read articles about the benefits of a high-fat diet as shown by residents of the Mediterranean, or even the benefits of green tea and high fish intake as shown by residents of Japan. It is worth noting that both areas of the world taut some of the highest life expectancy rates, with Japan having the highest in the world with women at 87 years and men at 80 years. But did you know about some other countries that are hailed as some of the healthiest in the world? Iceland and Sweden are just two. And it’s not just diet that is healthier about these countries; it’s lifestyle as well. How mindful you are when eating and stopping when you are 80 percent full are just a few cultural practices that make all the difference when it comes to having a healthy body weight and living a long life. Take a look below as we hone in on what makes each country so healthy.




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Dubrovnik, Croatia

Mediterranean area: Italy, Sardinia, Sicily, Greece, Croatia.

Dr. Ancel Keys coined the term Mediterranean diet in the 50’s, but the residents of the Mediterranean have known the benefits for thousands of years because for them it is a way of life. Their diet consists of tons of olive oil, small portions of nuts (walnuts and pine nuts are common,) wheat bread and pasta, moderate amounts of fish and poultry, cheese, yogurt, honey, a low intake of red meat and a moderate intake of red wine, and of course, lots and lots of fresh fruits and vegetables. The Mediterranean diet is praised for its ability to promote brain health and keep chronic diseases at bay. The Greek island of Ikaria and the Ogliastra region of Sardinia are two especially healthy places in the Mediterranean, as noted by author Dan Buettner in his book Blue Zones, which discusses the secrets of people in certain areas of the world who live the longest. Ikaria’s population eats a lot of legumes such as chickpeas, black-eyed peas, and lentils,  goat’s milk, wild greens, feta cheese, lemons, and herbs, while in the Ogliastra region of Sardinia, the population enjoys locally produced wine, goat’s milk and sheep’s cheese (15 pounds a year!) flatbread, sourdough bread, barley, fennel, fava beans, chickpeas, tomatoes, almonds, milk thistle tea.


Queensland, New Zealand

New Zealand:

New Zealand is known for its amazing landscapes, (if you’ve seen Lord of the Rings, you know what I’m talking about,) which makes it easy to enjoy an active lifestyle outdoors. Kiwi’s love to hike, swim (the beach is never more than 90 minutes away anywhere in the country,) camp, and fish. Queensland is considered the adventure capital of the world, with tourism being the countries second largest industry, drawing climbers, surfers, hikers, cyclists, skydivers, and bungee jumpers alike. New Zealand is also considered the most socially progressive country in the world and is extremely safe; NZ even tied with Denmark for first place as the least politically corrupt country on the planet. Kiwi’s also value education, and their literacy rate is 99 percent. (Reading is linked with lower stress levels which add years to your life.) There’s also less stress there due to low health care costs (often free,) and the food is mostly local and organic fruits, vegetables, and fresh seafood. As a result, life expectancy  in NZ is 83 for women, 80 for men.


Matsumoto Castle, Japan

Japan:

Japan has the highest life expectancy in the world, with women at 87 years and men not that far behind at 80 years. On the Japanese island of Okinawa specifically, about 6.5 in 10,000 people live to 100 which is a pretty large number (the U.S. is 1.73 in 10,000.) The Japanese incorporate movement into their everyday tasks, which attributes to low stress levels and cardiovascular health. The Japanese people also place high value on social networks, and it's been proven that an active social life can actually add years to your life. Their diet on Okinawa consists of bitter melons, tofu, garlic, brown rice, green tea, shiitake mushrooms, seaweed, turmeric, and sweet potatoes. In the entire country, as many as four or five varieties of vegetables are served at every meal, and the Japanese eat 10% of the world’s fish. They also include soy at every meal, such as miso soup and chunks of tofu, and serve their food on beautiful small plates that are pleasing to the eye and remind you to take it slow in order to savor your food and to stop when 80 percent full. And, of course, they consume green tea at the end of every meal, and we all know how healthy it is. (Especially matcha.)



Blue Lagoon geothermal spa, Grindavik, Iceland

Iceland:

Clean air might have something to do with the healthy residents of Iceland. Iceland is considered one of the least polluted countries in the world and has a minuscule population. It is chilly most of the time in Iceland as well, and Icelanders love to hit the gym to combat the cold; ice climbing, rock climbing, and kayaking are also popular. Their diet isn’t too shabby either, with loads of lamb, seafood (mostly cod, herring, and haddock,) dairy from grass fed free range cows, and olive oil; and there is minimal pesticide use due to most food being grown in greenhouses. Another trick they swear by is natural hot springs and steam rooms to release stress, improve cardiovascular function, and burn calories. Due to all of this, they have quite a high life expectancy in Iceland: 83 for women, 79 for men. 



Abisko Mountain Station, Sweden

Sweden:

The Swedish have consistently been on healthiest people lists for years, and their life expectancies are 83 for women, 78 for men. Saunas are an important part of Swedish culture just like in Iceland. In addition, exercise is incorporated into everyday life in Sweden, as 30 percent of Swedes that live in cities cycle to and from work, 50% of Swedes regularly take long walks for leisure, and joining teams and sports clubs is extremely common. Unhealthy food and oversized portions is not really a thing in Sweden, as going to a fast food restaurant and going to a regular restaurant cost the same, making it easier to choose the healthy option. Swedish food is similar to Iceland in that it includes a lot of fatty fish, root vegetables, and rye bread; they also tend to poach, ferment, smoke, and dry their foods. Another great plus in Sweden is the amount of Holiday time they receive; stretching up to five weeks a year. Vacation culture in Sweden is associated with low levels of depression and heart disease.



Kakslauttanen Arctic Resort, Finland

Finland:

One of the best success stories in the world, Finland went from a nation plagued by heart disease and couch potatoes to one of the fittest in the world. How did they do it in the relatively short span of thirty years? Implemented by the government, the health overhaul began in smaller cities where citizens were asked what type of physical activity they enjoyed; the government then provided these areas with places for recreational sports, national parks, put together teams, etc. They also made it a competition to bring down cholesterol and lower smoking rates, by hosting prize giveaways in the towns. Taking away all smoking billboards helped as well. Putting an emphasis on growing their own food, the government also took it upon themselves to get the citizens to eat better. Today, Finland is considered one of the healthiest countries in the world with a life expectancy of 83 for women, 78 for men, with its citizens enjoying plenty of physical activity, fresh food, and de-stressing activities, just like their Nordic neighbors. 



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Inspecting all of the diets of the healthiest countries in the world, I noticed a pattern in not only their food choices, with low levels of processed foods and high amounts of fresh vegetables and good fats, but in their lifestyles as well. Healthy people in these countries experience low levels of stress because they are always moving, and they always have an outlet in order to unwind; whether it’s sitting in a hot spring or sauna, joining a sports team, reading, drinking a glass of red wine (or beer or sake..,) meditating, and making sure to have a good work/life balance with plenty of resting time and vacation. Healthy cultures stop eating long before they're completely full, and are aware and mindful of the food they put into their bodies. Healthy cultures also have healthy social networks; as it’s been proven time and time again that a strong and supportive social system is key to reducing stress and living a healthy life. If we incorporated the tried and true tricks of other countries such as  these into our routines, we could add years to our lives, relieve stress, and be happier in general. Though I don't know about you, but learning about these places  just makes me want to buy a plane ticket. 



ClermontRadiology.com

Wednesday, August 3, 2016

New imaging technique helps surgeons remove more of tumor tissue in ovarian cancer patients.



A woman’s risk of getting ovarian cancer during her lifetime is about 1 in 75, it ranks fifth in deaths among American women, and it accounts for more deaths in the U.S. than any other cancer of the female reproductive system. The American Cancer Society estimates that in the United States in 2016, about 22,280 women will receive a new diagnosis of ovarian cancer and about 14,240 women will die from the disease. However, there is hope, and the rate at which women are diagnosed with ovarian cancer has been steadily slowing down over the past twenty years.

A new imaging technique that was tested in a small exploratory study led by Meiden University Medical Center in the Netherlands and published in the journal Clinical Cancer Research may help surgeons to find and remove nearly 30 percent more ovarian tumor tissue than normal. This tissue is critical in determining ovarian cancer patient survival, as leftover tissue from surgery is currently only removed by surgeons using just their eyes and hands.

Dr. Alexander L. Vahrmeijer, one of the study leaders, said that “Surgery is the most important treatment for ovarian cancer, and surgeons mainly have to rely on their naked eyes to identify tumor tissue, which is not optimal.”

The new technique that was used in the study uses a new type of fluorescent compound, and is called “near infrared (NIR) fluorescence imaging.” It uses a tumor-specific fluorescent agent and a dedicated imaging system in order to improve visualization of tumors during surgery. The way it works is that it detects the fluorescent signal in the tumor during surgery, thus making it easier to remove ovarian cancer tissue. The procedure is called cytoreduction.

Survival effect of maximal cytoreductive surgery.


Dr. Vahrmeijer explained “This allowed resection of additional tumor lesions that were not visible to the surgeons’ naked eyes,” and that, “Although more research is needed, this is hopefully the first step toward improving the surgical outcome of cancer patients.”

The fluorescent agent used is called OTL38, which is a combination of NIR fluorescent dye and a folate analog; it works by binding to a protein called folate receptor-alpha (FRa), which is expressed in more than 90 percent of ovarian cancers but in much lower levels in healthy tissue. The NIR light penetrates centimeters deep into tissue, and with the dedicated imaging system, this allows the surgeon to visualize tumors under the surface of the tissue.

During the study, the fluorescent agent was tested on a group of 30 healthy volunteers in a randomized, double-blind, placebo-controlled clinical trial. These results helped researchers figure out the optimal dose range and time window for using the agent in patients with ovarian cancer.
12 patients with ovarian cancer were then tested with OTL38 guided surgery. The compound was found to accumulate in FRa-positive tumors and metastases, and the surgeons successfully removed an additional 29 percent of malignant lesions that were not previously identifiable by naked eyes or hands. Pathology tests then confirmed that the removed tissue was indeed malignant.

A larger study is now being designed by the researchers, in order to calculate how well the technique identifies malignant tissue and how well it correctly rules out non-malignant tissue. Other fluorescent agents for other tumor types that do not express FRa will also be tested.

It is noted that only long term follow-up studies in large patient groups will show whether the technique improves survival, as stated by Dr. Vahrmeijer, “A limitation of this study is that we cannot say yet what the impact of our findings is on cure or survival of the patients. It is reasonable plausible to assume that if more cancer is removed the survival will be better.”